The Legend Of Zelda: The Skyward Sword.

[Kyleglor]

Oh yeah i found this

IGN: In past Zelda games, people noticed that Link was obviously left-handed. And I know that all the Zelda games are stand-alones -- but in this particular game, will there be a lefty option for left-handed people?

Aonuma: It's interesting because people say "all you have to do is switch it." But in reality, it's really hard. You have to change all the models -- you have to make two of everything. So really you're making two complete games, one left-handed version and one right-handed version. We just can't do that. For Twilight Princess, what we did was just create a mirror -- we flipped everything. And if that worked I guess we could do it that way, but again having to create two games is not something we want to do. We just hope that people will play it right-handed.

Source http://au.wii.ign.com/articles/109/1099184p2.html