A Look Into Side-Scrolling

[Goemar]

I don't think it matters if polygons or whatever is used as long as it suits the game. Bionic Commando Re-Armed for example looks good hot it is and couldn't imagine it not using polygons. A Megaman game in the cartoony look though would probably work.

It all depends on the game and what style best suits it. I think with any 2D game though art style has become a big thing such as with Braid, PixelJunk Eden and LocoRoco etc. all having distinct styles.