TSRpg

[~Axis~]

I would think that GameMaker would be best, you can make sprites and tiles freely with no limitations. It might have some drawbacks, but as long as you understand and know how to use it's programming language, it can be very powerful.

You should also check out BlitzMax (www.blitzbasic.com), although to use it, you'll need to have very good understanding of the BASIC programming language. Again, if you learn and understand the language, you can design your game without any limitations. You can't make sprites in the program though... Or at least I think... Check it out and see what you think.