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[Chutzpar]

Let me illustrate.

Here is a pretty lame joke, but with a proper delivery:

Person 1: What's the difference between a sandwich and a rabid dog?
Person 2: I don't know.
Person 1: ... I am never asking you to fix me lunch.

Here is the same joke with a similar setup to the girl gamer travesty and B^uckley:
Person 1: What's the difference between a sandwich and a rabid dog?
Person 2: I don't know.
Person 1: You don't know the difference between a sandwich and a rabid dog? So if I asked you for a sandwich you might bring me a rabid dog, instead? I am never asking you to fix me lunch!

If you explain the joke, it has failed.
If you explain the joke before the joke has even finished, it has failed doubly.

[Chutzpar]

Actually, with the girl gamer comic it's more like:

Person 1: What's the difference between a sandwich and a rabid dog?
Person 2: I don't know.
Person 1: You don't know the difference between a sandwich and a rabid dog? So if I asked you for a sandwich you might bring me a rabid dog, instead? I am never asking you to fix me lunch!
Person 2 hits person one

the last bit in a joke should be the punchline. So essentially the punchline here is the gothy looking girl having coffee thrown on her (which the artist was too lazy to even draw, so I had to actually reread that several times before I realised that's what happened).

That is why people can't find the joke. Because of the unnecessary framing.

[Chutzpar]

Watch me overexplain why you shouldn't overexplain a joke.

[Ashura]

who drew your avatar, dinosaurus

[Chutzpar]

It's from here!

http://maliki.com/

:>